I would run it the way I wanted it.. You will have some 40 inches more end grain running cross wise and there will be more movement *because. There will be more boards needed to to span the 65" than 44".
However if you run them long ways and add a Tough and groove Beard board covering the end grain. Just make sure you only glue or pin the bread board in the center and use screws (from the bottom side)with over size holes for movement or better still peg the board and slot the outside holes inside the bread board for expansion and contraction (movement ) of the table top.

-- Soli Deo gloria! ( To God alone be the Glory)